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News

Novel mechanisms for control of nuclear stability (Nature Cell Biology 10/2019)

Nuclear nano-structure and -mechanics are important determinants of cell behaviour such as proliferation and migration. This publication describes the role of histone acetyltransferase MOF in acetylating nuclear lamin, and thus exerting control of the structural and mechanical integrity of the nucleus. MOF-deficient cells display pronounced nuclear abnormal- ities such as fuzzy lamina and disrupted heterochromatin domains (assessed by        Dr Eva Rog-Zielinska using electron microscopy), and decreased nuclear stiffness and in consequence proneness to rupture (investigated by Dr Rémi Peyronnet using nano-indentation). The overall work describes novel mechanisms for control of nuclear stability, with important implications for the processes such as ageing and cancer growth, and has been jointly conducted with the laboratory of Dr Asifa Akhtar at the MPI for Immunobiology and Epigenetics in Freiburg. [direct link to article]

Genetic trigger discovered for mitral valve prolapse (Science Translational Medicine 05/2019)

Although mitral valve prolapse is one of the most common heart diseases, the cause was completely unknown. Until today.
An international team of researchers led by  Russel A Norris, Professor at the renowned Medical University of South Carolina, has now been able to show that genetic defects in the primary cilia of the heart valve cells during embryonic development are the triggers of this heart disease. If these cilia - cellular antennas receiving signals from their environment - are defective or even non-existent, the cells lose their ability to grow correctly. As a result, the normal structure of the valve changes and over time leads to mitral valve insufficiency.
The IEKM team around Dr Eva Rog-Zielinska provided the irrefutable proof that the structures observed are indeed primary cilia. This required 3D electron microscopic reconstructions of the nano-structure at a resolution of 1nm3. [direct link to article]

Gordon Research Conference on Cardiac Arrhythmia Mechanisms 2019

The recent GRC on Cardiac Arrhythmia Mechanisms and it's associated Gordon Research Seminar (GRS) was a great success to IEKM.

We had 2 invited lectures at GRS (Enaam Chleilat and Ramona Emig), one poster selected talk
(Marbely Calderón-Fernández) and one invited lecture (Eva Rog-Zielinska) at GRC.
Enaam Chleilat was awarded the best GRS talk, and was therefore invited to present at GRC. Ana Simón Chica was awarded the first poster prize. CONGRATULATIONS!

Best Manuscript Award (Circulation Research 11/2018)

The paper by Kensuke Tsushima et al has been awarded one of five Best Manuscript Awards by the Editors of Circulation Research. Dr Eva Rog-Zielinska from IEKM contributed 3D electron microscopic reconstructions, which revealed snake-like remodelling of mitochondria in diseased heart that would have been mis-interpreted as an accumulation of many small mitochondria in 2D sections. This image was previously selected for a Biomedical Picture of the day. [press release] [direct link to article]

Emmy Noether Fellowship for Dr Franziska Schneider-Warme (11/2018)

The DFG has awarded Dr Franziska Schneider-Warme as an excellent scientist with an Emmy Noether Fellowship. As head of a junior research group, she and her team will focus on the topic of "Optical steering of cellular biophysics in native myocardium: illuminating interstitial and myeloid cell contributions to cardiac electrophysiology". [official press release]

New Light-Switch to Inhibit Cells (Nature Communications, 11/2018)

Optogenetics is a dynamic research field wherein cell biological questions are assessed using light. A newly developed optogenetic system enables the targeted suppression of electrical impulses and their conduction upon illumination by short blue-light flashes. [official press release] [direct link to article]

Emmy Noether Fellowship for Dr Eva Rog-Zielinska (06/2018)

The DFG has awarded Dr Eva Rog-Zielinska as an excellent scientist with an Emmy Noether Fellowship. As head of a junior research group, she and her team will focus on the topic of "Dynamic mapping of heart cell 3D ultrastructure and function ". [official press release]

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