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Universitäts-Herzzentrum Freiburg - Bad KrozingenUniversitäts-Herzzentrum Freiburg - Bad Krozingen


AG Atherogenese


von Elverfeldt D, Meißner M, Peter K, Paul D, Meixner F, Neudorfer I, Merkle A, Harloff A, Zirlik A, Schöllhorn J, Markl M, Hennig J, Bode C, von Zur Muhlen C.
An approach towards molecular imaging of activated platelets allows imaging of symptomatic human carotid plaques in a new model of a tissue flow chamber.
Contrast Media Mol Imaging. 2012 Mar;7(2):204-213. doi: 10.1002/cmmi.482.
PMID: 22434633  [PubMed]

Wolf D, Jehle F, Ortiz Rodriguez A, Dufner B, Hoppe N, Colberg C, Lozhkin A, Bassler N, Rupprecht B, Wiedemann A, Hilgendorf I, Stachon P, Willecke F, Febbraio M, Binder CJ, Bode C, Zirlik A, Peter K.
CD40L Deficiency Attenuates Diet-Induced Adipose Tissue Inflammation by Impairing Immune Cell Accumulation and Production of Pathogenic IgG-Antibodies.

PLoS One. 2012;7(3):e33026. Epub 2012 Mar 8.
PMID: 22412980 [PubMed]  

von Zur Muhlen C, Schiffer E, Sackmann C, Zürbig P, Neudorfer I, Zirlik A, Htun N, Iphöfer A, Jänsch L, Mischak H, Bode C, Chen YC, Peter K.
Urine proteome analysis reflects atherosclerotic disease in an ApoE-/- mouse model and allows the discovery of new biomarkers in mouse and human atherosclerosis.
Mol Cell Proteomics. 2012 Feb 27. [Epub ahead of print]
PMID: 22371488 [PubMed]

Reuland AK, Engelhardt M, Meyer PT, Stroh AL, Lübbert M, Finke J, Schmitt-Gräff A, Zirlik A, Wäsch R.
Aggressive plasmablastic lymphoproliferation complicated by hemophagocytic syndrome 12 years after heart transplantation.
Leuk Lymphoma. 2012 Feb 15. [Epub ahead of print].
PMID: 22335533 [Pubmed]

Wolf D, Hohmann JD, Wiedemann A, Bledzka K, Blankenbach H, Marchini T, Gutte K, Zeschky K, Bassler N, Hoppe N, Rodriguez AO, Herr N, Hilgendorf I, Stachon P, Willecke F, Duerschmied D, von Zur Muhlen C, Soloviev DA, Zhang L, Bode C, Plow EF, Libby P, Peter K, Zirlik A
Binding of CD40L to Mac-1's I-Domain Involves the EQLKKSKTL Motif and Mediates Leukocyte Recruitment and Atherosclerosis--But Does Not Affect Immunity and Thrombosis in Mice.
Circ Res. 2011 Nov 11;109(11):1269-79. Epub 2011 Oct 13.
PMID:21998326 [Pubmed]

Gerdes N, Zirlik A
Co-stimulatory molecules in and beyond co-stimulation - tipping the balance in atherosclerosis?
Thromb Haemost. 2011 Nov 3;106(5):804-13. Epub 2011 Oct 6.
PMID:21979444 [Pubmed]

Hilgendorf I, Eisele S, Remer I, Schmitz J, Zeschky K, Colberg C, Stachon P, Wolf D, Willecke F, Buchner M, Zirlik K, Ortiz-Rodriguez A, Lozhkin A, Hoppe N, von zur Muhlen C, zur Hausen A, Bode C, Zirlik A
The oral spleen tyrosine kinase inhibitor fostamatinib attenuates inflammation and atherogenesis in low-density lipoprotein receptor-deficient mice.
Arterioscler Thromb Vasc Biol. 2011 Sep;31(9):1991-9. Epub 2011 Jun 23.
PMID:21700926 [Pubmed]

Duerschmied D, Meissner M, Peter K, Neudorfer I, Roming F, Zirlik A, Bode C, von Elverfeldt D, von Zur Muhlen C.
Molecular Magnetic Resonance Imaging Allows the Detection of Activated Platelets in a New Mouse Model of Coronary Artery Thrombosis.
Invest Radiol. 2011 May 26. [Epub ahead of print]
PMID: 21577120 [Pubmed]

Willecke F, Zeschky K, Ortiz Rodriguez A, Colberg C, Auwärter V, Kneisel S, Hutter M, Lozhkin A, Hoppe N, Wolf D, von Zur Mühlen C, Moser M, Hilgendorf I, Bode C, Zirlik A.
Cannabinoid receptor 2 signaling does not modulate atherogenesis in mice.
PLoS One. 2011 Apr 26;6(4):e19405.
PMID: 21541300 [Pubmed]

Heidt T, Deininger F, Peter K, Goldschmidt J, Pethe A, Hagemeyer CE, Neudorfer I, Zirlik A, Weber WA, Bode C, Meyer PT, Behe M, von Zur Mühlen C.
Activated platelets in carotid artery thrombosis in mice can be selectively targeted with a radiolabeled single-chain antibody.
PLoS One. 2011 Mar 30;6(3):e18446.
PMID: 21479193 [Pubmed]

Missiou A, Rudolf P, Stachon P, Wolf D, Varo N, Aichele P, Colberg C, Hoppe N, Ernst S, Münkel C, Walter C, Sommer B, Hilgendorf I, Nakano H, Bode C, Zirlik A.
TRAF5 Deficiency Accelerates Atherogenesis in Mice by Increasing Inflammatory Cell Recruitment and Foam Cell Formation.
Circ Res. 2010 Sep 17;107(6):757-66. Epub 2010 Jul 22.
PMID: 20651286 [Pubmed]

Stachon P, Missiou A, Walter C, Varo N, Colberg C, Wolf D, Buchner M, von Zur Mühlen C, Zirlik K, Bode C, Zirlik A.
Tumor necrosis factor receptor associated factor 6 is not required for atherogenesis in mice and does not associate with atherosclerosis in humans.
PLoS One. 2010 Jul 14;5(7):e11589. 101(6):1060-9.
PMID: 19492148 [Pubmed]

Missiou A., Köstlin N., Varo N., Rudolf P., Aichele P., Ernst S., Münkel C., Walter C., Stachon P., Sommer B., Pfeifer D., Zirlik K., MacFarlane L., Wolf D., Tsitsikov E., Bode C., Libby P., Zirlik A.
TRAF1 deficiency attenuates atherosclerosis in mice by impairing monocyte recruitment to the vessel wall.
Circulation. 2010 May 11;121(18):2033-44. Epub 2010 Apr 26. PMID: 20421522; [Pubmed]

Missiou A., Wolf D., Platzer I., Ernst S., Walter C., Rudolf P., Zirlik K., Köstlin N., Willecke F., Münkel C., Schönbeck U, Libby P., Bode C., Varo N., Zirlik A.
CD40L induces inflammation and adipogenesis in adipose cells – a potential link between metabolic and cardiovascular disease.
Thromb Haemost. 2010 Mar 31;103(4):788-96. Epub 2010 Feb 19.
PMID: 20174757; [Pubmed]

Zirlik A., Ernst S., Leugers A., Willecke F., Sobel B.E., Bode C., Nordt T.K.
Inhibition by fibrates of plaminogen activator inhibitor type-1 expression in human adipocytes and preadipocytes.
Thromb Haemost 2009 Jun; 101(6):1060-9.
PMID: 19492148 [Pubmed]

Hartmann M, Bode C, Zirlik A.Hartmann M, Bode C, Zirlik A.
Anaphylactic shock-associated cardiomyopathy.
Int J Cardiol. 2007 Jul 23;
PMID: 17651828 [Pubmed]

Mollmann H, Zirlik A, Nef HM, Weber M, Hamm CW, Elsasser A.
Left ventricular tamponade - a clinical chameleon.
Thorac Cardiovasc Surg. 2007 Aug;55(5):325-7.
PMID: 17629866 [Pubmed]

Zirlik A, Abdullah SM, Gerdes N, MacFarlane L, Schonbeck U, Khera A, McGuire DK, Vega GL, Grundy S, Libby P, de Lemos JA.
Interleukin-18, the metabolic syndrome, and subclinical atherosclerosis: results from the Dallas Heart Study.
Arterioscler Thromb Vasc Biol. 2007 Sep;27(9):2043-9. Epub 2007 Jul 12.
PMID: 17626902 [Pubmed]

Bode C, Zirlik A.
STEMI and NSTEMI: the dangerous brothers.
Eur Heart J. 2007 Jun;28(12):1403-4. Epub 2007 May 24. No abstract available.
PMID: 17526505 [Pubmed]

Zirlik A, Maier C, Gerdes N, MacFarlane L, Soosairajah J, Bavendiek U, Ahrens I, Ernst S, Bassler N, Missiou A, Patko Z, Aikawa M, Schonbeck U, Bode C, Libby P, Peter K.
CD40 ligand mediates inflammation independently of CD40 by interaction with Mac-1.
Circulation. 2007 Mar 27;115(12):1571-80. Epub 2007 Mar 19.
PMID: 17372166 [Pubmed]

Zirlik A, Bavendiek U, Libby P, MacFarlane L, Gerdes N, Jagielska J, Ernst S, Aikawa M, Nakano H, Tsitsikov E, Schonbeck U.
TRAF-1, -2, -3, -5, and -6 are induced in atherosclerotic plaques and differentially mediate proinflammatory functions of CD40L in endothelial cells.
Arterioscler Thromb Vasc Biol. 2007 May;27(5):1101-7. Epub 2007 Mar 1.
PMID: 17332487 [PubMed]

Mauerer K, Krauss T, Zirlik A.
Mycotic aneurysm complicating prosthetic valve endocarditis.
Heart. 2006 Nov;92(11):1550.
PMID: 17041106 [Pubmed]

Isoda K, Young JL, Zirlik A, MacFarlane LA, Tsuboi N, Gerdes N, Schonbeck U, Libby P.
Metformin inhibits proinflammatory responses and nuclear factor-kappaB in human vascular wall cells.
Arterioscler Thromb Vasc Biol. 2006 Mar;26(3):611-7. Epub 2005 Dec 29.
PMID: 16385087 [Pubmed]

de Lemos JA, Zirlik A, Schonbeck U, Varo N, Murphy SA, Khera A, McGuire DK, Stanek G, Lo HS, Nuzzo R, Morrow DA, Peshock R, Libby P.
Associations between soluble CD40 ligand, atherosclerosis risk factors, and subclinical atherosclerosis: results from the Dallas Heart Study.
Arterioscler Thromb Vasc Biol. 2005 Oct;25(10):2192-6. Epub 2005 Aug 18.
PMID: 16109925 [Pubmed]

Zirlik A, Nordt TK.
Massive air embolism after Maze.

Heart. 2005 Jun;91(6):736. No abstract available.
PMID: 15894764 [Pubmed]

Bavendiek U, Zirlik A, LaClair S, MacFarlane L, Libby P, Schonbeck U.
Atherogenesis in mice does not require CD40 ligand from bone marrow-derived cells.
Arterioscler Thromb Vasc Biol. 2005 Jun;25(6):1244-9. Epub 2005 Mar 3.
PMID: 15746436 [Pubmed]

Zirlik A, Leugers A, Lohrmann J, Ernst S, Sobel BE, Bode C, Nordt TK.
Direct attenuation of plasminogen activator inhibitor type-1 expression in human adipose tissue by thiazolidinediones.
Thromb Haemost. 2004 Apr;91(4):674-82.
PMID: 15045127 [Pubmed]

Zirlik A.
TAFI: a promising drug target?
Thromb Haemost. 2004 Mar;91(3):420-2.
PMID: 15025077 [Pubmed]

Zotz RJ, Zirlik A, Raeder T, Hahn M, Binner C, Ullmann C, Grimm M, Schuler G.
Three-dimensional visualization of coronary arteries in excised hearts.
J Am Soc Echocardiogr. 2001 Jan;14(1):11-9.
PMID: 11174429 [Pubmed]


Prof. Dr. Zirlik
Telefon: +49 761 270-70380
Telefax: +49 761 270-70060

Sekretariat Klinik
Telefon: +49 761 270-34415
Telefax: +49 761 270-34426