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Universitäts-Herzzentrum Freiburg - Bad KrozingenUniversitäts-Herzzentrum Freiburg - Bad Krozingen


Cardiac Energy Metabolism



1. Wende AR, O`Neill BT, Bugger H, Riehle C, Tuinei J, Buchanan J, Tsushima K, Wang L, Caro P, Guo A, Sloan C, Kim BJ, Wang X, Pereira RO, Benavides GA, Darley-Usmar VM, Shioi T, Weimer BC, Abel ED. Akt/PKB signaling induces mitochondrial dysfunction in pathological cardiac hypertrophy via transcriptional repression of nuclear-encoded mitochondrial genes. Mol Cell Biol. 2014 In press [PubMed]

2. Riehle C, Wende AR, Sena S, Pires KM, Pereira RO, Zhu Y, Bugger H, Frank D, Bevins J, Chen D, Perry CN, Dong XC, Valdez S, Rech M, Sheng X, Weimer BC, Gottlieb RA, White MF, Abel ED. Insulin receptor substrate signaling suppresses neonatal autophagy in the heart. J Clin Invest. 2013;123(12):5319-33 [PubMed]

3. Bugger H, Bode C. The vulnerable myocardium. Diabetic cardiomyopathy. Hämostaseologie. 2014 35(1): Epub ahead of print

4. Bugger H, Abel ED. Molecular mechanisms of diabetic cardiomyopathy. Diabetologia. 2014. 57(4):660-71 [PubMed]


3. Zhu Y, Pires KM, Whitehead KJ, Olsen CD, Wayment B, Zhang YC, Bugger H, Ilkun O, Litwin SE, Thomas G, Kozma SC, Abel ED. Mechanistic target of rapamycin (mTOR) is essential for murine embryonic heart development and growth. PLoS One. 2013;8(1):e54221 [PubMed]


4. Bugger H, Riehle C, Jaishy B, Wende AR, Tuinei J, Chen D, Soto J, Pires KM, Boudina S, Theobald HA, Luptak I, Wayment B, Wang X, Litwin SE, Weimer BC, Abel ED. Genetic loss of insulin receptors worsens cardiac efficiency in diabetes. J Mol Cell Cardiol. 2012;52(5):1019-26 [PubMed]

5. König A, Bode C, Bugger H. Diabetes mellitus and myocardial mitochondrial dysfunction: bench to bedside. Heart Fail Clin 2012; 8(4):551-61 [PubMed]
6. Bugger H, Abel ED. Endonuclease G: The link between mitochondria and cardiac hypertrophy? Circ Res. 2012; 110(3):378-80 [PubMed]


5. Riehle C, Wende AR, Zaha VG, Pires KM, Wayment B, Olsen C, Bugger H, Buchanan J, Wang X, Moreira AB, Doenst T, Medina-Gomez G, Litwin SE, Lelliott CJ, Vidal-Puig A, Abel ED. PGC-1(beta) deficiency accelerates the transition to heart failure in pressure overload hypertrophy. Circ Res. 2011;109(7):783-93 [PubMed]

6. Sloan C, Tuinei J, Nemetz K, Frandsen J, Soto J, Wride N, Sempokuya T, Alegria L, Bugger H, Abel ED. Central leptin signaling is required to normalize myocardial fatty acid oxidation rates in caloric-restricted ob/ob mice. Diabetes. 2011;60(5):1424-34 [PubMed]

7. Bugger H, Guzman C, Zechner C, Palmeri M, Russell KS, Russell RR 3rd. Uncoupling protein downregulation in doxorubicin-induced heart failure improves mitochondrial coupling but increases reactive oxygen species production. Cancer Chemother Pharmacol. 2011;67(6):1381-8 [PubMed]


10. Bugger H, Schwarzer M, Chen D, Schrepper A, Amorim PA, Schoepe M, Nguyen TD, Mohr FW, Khalimonchuk O, Weimer BC, Doenst T. Proteomic Remodeling of Mitochondrial Oxidative Pathways in Pressure Overload-induced Heart Failure. Cardiovasc Res. 2010;85(2):376-384. [PubMed]

11. Bugger H, Abel ED. Mitochondria in the diabetic heart. Cardiovasc Res. 2010;88(2):229-40 [PubMed]


8. Liu S, Okada T, Assmann A, Soto J, Liew CW, Bugger H, Shirihai OS, Abel ED, Kulkarni RN. Insulin signaling regulates mitochondrial function in pancreatic beta-cells. PLoS One. 2009;4(11):e7983 [PubMed]

9. Bugger H, Chen D, Riehle C, Soto J, Theobald HA, Hu XX, Ganesan B, Weimer BC, Abel ED. Tissue-specific remodeling of the mitochondrial proteome in type 1 diabetic akita mice. Diabetes. 2009;58(9):1986-1997. [PubMed]

11. Boudina S, Bugger H, Sena S, O'Neill BT, Zaha VG, Ilkun O, Wright JJ, Mazumder PK, Palfreyman E, Tidwell TJ, Theobald H, Khalimonchuk O, Wayment B, Sheng X, Rodnick KJ, Centini R, Chen D, Litwin SE, Weimer BE, Abel ED. Contribution of impaired myocardial insulin signaling to mitochondrial dysfunction and oxidative stress in the heart. Circulation. 2009;119(9):1272-1283. [PubMed]

12. Bugger H, Abel ED. Rodent models of diabetic cardiomyopathy. Dis Model Mech. 2009;2(9-10):454-466.


13. Bugger H, Boudina S, Hu XX, Tuinei J, Zaha VG, Theobald HA, Yun UJ, McQueen AP, Wayment B, Litwin SE, Abel ED. Type 1 diabetic akita mouse hearts are insulin sensitive but manifest structurally abnormal mitochondria that remain coupled despite increased uncoupling protein 3. Diabetes. 2008;57(11):2924-2932.

14. Bray MS, Shaw CA, Moore MW, Garcia RA, Zanquetta MM, Durgan DJ, Jeong WJ, Tsai JY, Bugger H, Zhang D, Rohrwasser A, Rennison JH, Dyck JR, Litwin SE, Hardin PE, Chow CW, Chandler MP, Abel ED, Young ME. Disruption of the circadian clock within the cardiomyocyte influences myocardial contractile function, metabolism, and gene expression. Am J Physiol Heart Circ Physiol. 2008;294(2):H1036-1047. [PubMed]

15. Doenst T, Bugger H, Schwarzer M, Faerber G, Borger MA, Mohr FW. Three good reasons for heart surgeons to understand cardiac metabolism. Eur J Cardiothorac Surg. 2008;33(5):862-871. [PubMed]

16. Bugger H, Abel ED. The metabolic syndrome and cardiac function. Adv Pulm Hypertens. 2008;3:332-336.

17. Bugger H, Abel ED. Molecular basis of cardiac efficiency. Heart Metab. 2008;39:5-9.

18. Bugger H, Abel ED. Molecular mechanisms for myocardial mitochondrial dysfunction in the metabolic syndrome. Clin Sci (Lond). 2008;114(3):195-210. [PubMed]


19. Boudina S, Sena S, Theobald H, Sheng X, Wright JJ, Hu XX, Aziz S, Johnson JI, Bugger H, Zaha VG, Abel ED. Mitochondrial energetics in the heart in obesity-related diabetes: direct evidence for increased uncoupled respiration and activation of uncoupling proteins. Diabetes. 2007;56(10):2457-2466. [PubMed]


15. Doenst T, Bugger H, Leippert S, Barleon B, Marme D, Beyersdorf F. Differential gene expression in response to ventricular unloading in rat and human myocardium. Thorac Cardiovasc Surg. 2006;54(6):381-387.

20. Bugger H, Leippert S, Blum D, Kahle P, Barleon B, Marme D, Doenst T. Subtractive hybridization for differential gene expression in mechanically unloaded rat heart. Am J Physiol Heart Circ Physiol. 2006;291(6):H2714-2722.[PubMed]

21. Bugger H, Chemnitius JM, Doenst T. Differential changes in respiratory capacity and ischemia tolerance of isolated mitochondria from atrophied and hypertrophied hearts. Metabolism. 2006;55(8):1097-1106. [PubMed]

PD Dr. Heiko Bugger

PD Dr. med. Heiko Bugger
Principal Investigator