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Publications

2019

Psychiatric Presentation of Anti-NMDA Receptor Encephalitis.
Endres D, Rauer S, Kern W, Venhoff N, Maier SJ, Runge K, Süß P, Feige B, Nickel K, Heidt T, Domschke K, Egger K, Prüss H, Meyer PT, Tebartz van Elst L.
Front Neurol. 2019 Nov 5;10:1086. [PubMed]

Real-time magnetic resonance imaging - guided coronary intervention in a porcine model.
Heidt T, Reiss S, Krafft AJ, Özen AC, Lottner T, Hehrlein C, Galmbacher R, Kayser G, Hilgendorf I, Stachon P, Wolf D, Zirlik A, Düring K, Zehender M, Meckel S, von Elverfeldt D, Bode C, Bock M, Mühlen CVZ.
Sci Rep. 2019 Jun 17;9(1):8663. [PubMed]  

Nationwide outcomes of aortic valve replacement for pure aortic regurgitation in Germany 2008-2015.
Stachon P, Kaier K, Heidt T, Bothe W, Zirlik A, Zehender M, Bode C, von Zur Mühlen C.
Catheter Cardiovasc Interv. 2019 Jun 4. doi: 10.1002/ccd.28361. [PubMed]  

Risk-Adjusted Comparison of In-Hospital Outcomes of Transcatheter and Surgical Aortic Valve Replacement. Stachon P, Kaier K, Zirlik A, Bothe W, Heidt T, Zehender M, Bode C, von Zur Mühlen C.
J Am Heart Assoc. 2019 Apr 2;8(7):e011504. doi: 10.1161/JAHA.118.011504. [PubMed]

2018

Purinergic receptor Y2 (P2Y2)- dependent VCAM-1 expression promotes immune cell infiltration in metabolic syndrome.
Merz J, Albrecht P, von Garlen S, Ahmed I, Dimanski D, Wolf D, Hilgendorf I, Härdtner C, Grotius K, Willecke F, Heidt T, Bugger H, Hoppe N, Kintscher U, von Zur Mühlen C, Idzko M, Bode C, Zirlik A, Stachon P.
Basic Res Cardiol. 2018 Oct 18;113(6):45. [PubMed]  

Risk factors and outcome of postoperative delirium after transcatheter aortic valve replacement.
Stachon P, Kaier K, Zirlik A, Reinöhl J, Heidt T, Bothe W, Hehn P, Zehender M, Bode C, von Zur Mühlen C. Clin Res Cardiol. 2018 Sep;107(9):756-762. [PubMed]

Coronary magnetic resonance imaging after routine implantation of bioresorbable vascular scaffolds allows non-invasive evaluation of vascular patency.
von Zur Mühlen C, Reiss S, Krafft AJ, Besch L, Menza M, Zehender M, Heidt T, Maier A, Pfannebecker T, Zirlik A, Reinöhl J, Stachon P, Hilgendorf I, Wolf D, Diehl P, Wengenmayer T, Ahrens I, Bode C, Bock M.
PLoS One. 2018 Jan 25;13(1):e0191413. [PubMed]

Inflammatory Pathways Regulated by Tumor Necrosis Receptor-Associated Factor 1 Protect From Metabolic Consequences in Diet-Induced Obesity.
Anto Michel N, Colberg C, Buscher K, Sommer B, Pramod AB, Ehinger E, Dufner B, Hoppe N, Pfeiffer K, Marchini T, Willecke F, Stachon P, Hilgendorf I, Heidt T, von Zur Muhlen C, von Elverfeldt D, Pfeifer D, Schüle R, Kintscher U, Brachs S, Ley K, Bode C, Zirlik A, Wolf D.
Circ Res. 2018 Mar 2;122(5):693-700. [PubMed]    

2017

A molecular intravascular ultrasound contrast agent allows detection of activated platelets on the surface of symptomatic human plaques.
Maier A, Plaza-Heck P, Meixner F, Guenther F, Kaufmann BA, Kramer M, Heidt T, Zirlik A, Hilgendorf I, Reinöhl J, Stachon P, Bronsert P, Birkemeyer R, Neudorfer I, Peter K, Bode C, von Zur Mühlen C.
Atherosclerosis. 2017 Dec;267:68-77. doi: 10.1016/j.atherosclerosis.2017.10.029. Epub 2017 Oct 24.  [PubMed]  

Dual targeting improves capture of ultrasound microbubbles towards activated platelets but yields no additional benefit for imaging of arterial thrombosis.
Günther F, Heidt T, Kramer M, Khanicheh E, Klibanov AL, Geibel-Zehender A, Ferrante EA, Hilgendorf I, Wolf D, Zirlik A, Reinöhl J, Bode C, Peter K, Kaufmann BA, Mühlen CVZ.
Sci Rep. 2017 Nov 2;7(1):14898. doi: 10.1038/s41598-017-15080-7. [PubMed]  

2016

Proliferation and Recruitment Contribute to Myocardial Macrophage Expansion in Chronic Heart Failure.
Sager HB, Hulsmans M, Lavine KJ, Moreira MB, Heidt T, Courties G, Sun Y, Iwamoto Y, Tricot B, Khan OF, Dahlman JE, Borodovsky A, Fitzgerald K, Anderson DG, Weissleder R, Libby P, Swirski FK, Nahrendorf M.
Circ Res. 2016 Sep 16;119(7):853-64. doi: 10.1161/CIRCRESAHA.116.309001. Epub 2016 Jul 21. [PubMed]  

RNAi targeting multiple cell adhesion molecules reduces immune cell recruitment and vascular inflammation after myocardial infarction.
Sager HB, Dutta P, Dahlman JE, Hulsmans M, Courties G, Sun Y, Heidt T, Vinegoni C, Borodovsky A, Fitzgerald K, Wojtkiewicz GR, Iwamoto Y, Tricot B, Khan OF, Kauffman KJ, Xing Y, Shaw TE, Libby P, Langer R, Weissleder R, Swirski FK, Anderson DG, Nahrendorf M.
Sci Transl Med. 2016 Jun 8;8(342):342ra80. doi: 10.1126/scitranslmed.aaf1435. [PubMed]  

Molecular Imaging of Activated Platelets Allows the Detection of Pulmonary Embolism with Magnetic Resonance Imaging.
Heidt T, Ehrismann S, Hövener JB, Neudorfer I, Hilgendorf I, Reisert M, Hagemeyer CE, Zirlik A, Reinöhl J, Bode C, Peter K, von Elverfeldt D, von Zur Muhlen C.
Sci Rep. 2016 May 3;6:25044. doi: 10.1038/srep25044. [PubMed] 

Atheroprotection through SYK inhibition fails in established disease when local macrophage proliferation dominates lesion progression.
Lindau A, Härdtner C, Hergeth SP, Blanz KD, Dufner B, Hoppe N, Anto-Michel N, Kornemann J, Zou J, Gerhardt LM, Heidt T, Willecke F, Geis S, Stachon P, Wolf D, Libby P, Swirski FK, Robbins CS, McPheat W, Hawley S, Braddock M, Gilsbach R, Hein L, von zur Mühlen C, Bode C, Zirlik A, Hilgendorf I.
Basic Res Cardiol. 2016 Mar;111(2):20. [PubMed]

2015

4D-cardiac CT and IVUS support stenting of left main compression due to an enlarged pulmonary artery.
Heidt T, Büttner HJ,Löffelhardt N, Minners J,Langer M,Neumann FJ, Bode C, Pache G.
EuroIntervention. 2015 Dec 22;11(8):e1. [PubMed]

Targeting Interleukin-1β Reduces Leukocyte Production After Acute Myocardial Infarction.
Sager HB, Heidt T, Hulsmans M, Dutta P, Courties G, Sebas M, Wojtkiewicz GR, Tricot B, Iwamoto Y, Sun Y, Weissleder R, Libby P, Swirski FK, Nahrendorf M.
Circulation. 2015 Nov 17;132(20):1880-90. [PubMed]

Preprocedural planning and implantation of a transcatheter aortic valve without the use of contrast agent. Reinöhl J, Pache G, Ahrens I, Heidt T, Psyrakis D, Latib A, De Marco F, Schröfel H, Beyersdorf F, Zehender M, Bode C, von Zur Mühlen C.
EuroIntervention. 2015 Jul 9;11(3). pii: 20150527-02. [PubMed]

Myocardial Infarction Activates CCR2(+) Hematopoietic Stem and Progenitor Cells.
Dutta P, Sager HB, Stengel KR, Naxerova K, Courties G, Saez B, Silberstein L, Heidt T, Sebas M, Sun Y, Wojtkiewicz G, Feruglio PF, King K, Baker JN, van der Laan AM, Borodovsky A, Fitzgerald K, Hulsmans M, Hoyer F, Iwamoto Y, Vinegoni C, Brown D, Di Carli M, Libby P, Hiebert SW, Scadden DT, Swirski FK, Weissleder R, Nahrendorf M.
Cell Stem Cell. 2015 May 7;16(5):477-87. [PubMed]

Magnetic resonance imaging of bioresorbable vascular scaffolds: potential approach for noninvasive evaluation of coronary patency.
Reiss S, Krafft AJ, Zehender M, Heidt T, Pfannebecker T, Bode C, Bock M, von Zur Muhlen C.
Circ Cardiovasc Interv. 2015 Apr;8(4). pii: e002388 [PubMed]

Ischemic stroke activates hematopoietic bone marrow stem cells.
Courties G, Herisson F, Sager HB, Heidt T, Ye Y, Wei Y, Sun Y, Severe N, Dutta P, Scharff J, Scadden DT, Weissleder R, Swirski FK, Moskowitz MA, Nahrendorf M.
Circ Res. 2015 Jan 30;116(3):407-17. [PubMed]

2014

Chronic variable stress activates hematopoietic stem cells.
Timo Heidt, Hendrik B. Sager, Gabriel Courties, Partha Dutta, Yoshiko Iwamoto, Alex Zaltsman, Constantin von zur Muhlen, Christoph Bode, Gregory L. Fricchione, John Denninger, Charles P. Lin, Claudio Vinegoni, Peter Libby, Filip K. Swirski, Ralph Weissleder, Matthias Nahrendorf.
Nature Medicine 2014 June 22. [PubMed]

Dual contrast molecular imaging allows noninvasive characterization of myocardial ischemia-reperfusion injury after coronary vessel occlusion in mice by MRI.
von Elverfeldt D, Maier A, Duerschmied D, Braig M, Idzko M, Neudorfer I, Menzer, M, Zirlik A, Heidt T, Mauler M, Bode C, Peter K, von zur Muhlen C.
Circulation 2014 Jun 20. [PubMed]

Molecular Imaging of Vascular Thrombosis
Timo Heidt, Felix Günther, Marvin Krohn-Grimberghe, Karlheinz Peter, Christoph Bode and Constantin von zur Muhlen.
Current Molecular Imaging, 2014, 3, 27-36. [ingentaconnect]

Differential Contribution of Monocytes to Heart Macrophages in Steady-State and
After Myocardial Infarction.

Heidt T, Courties G, Dutta P,Sager H, Sebas M, Iwamoto Y, Sun Y, Da Silva N, Panizzi P, van der Laan AM, Swirski FK, Weissleder R, Nahrendorf M.
Circ Res. 2014 May 1. [PubMed]

In vivo silencing of the transcription factor IRF5 reprograms the macrophage phenotype and improves infarct healing.
Courties G, Heidt T, Sebas M, Iwamoto Y, Jeon D, Truelove J, Tricot B, Wojtkiewicz G, Dutta P, Sager HB, Borodovsky A, Novobrantseva T, Klebanov B, Fitzgerald K, Anderson DG, Libby P, Swirski FK, Weissleder R, Nahrendorf M. J
Am Coll Cardiol. 2014 Apr 22;63(15):1556-66. [PubMed]

2013

Multimodal iron oxide nanoparticles for hybrid biomedical imaging.
Heidt T, Nahrendorf M.
NMR Biomed. 2013 Jul;26(7):756-65. [PubMed]

Monocyte-directed RNAi targeting CCR2 improves infarct healing in atherosclerosis-prone mice.
Majmudar MD, Keliher EJ, Heidt T, Leuschner F, Truelove J, Sena BF, Gorbatov R, Iwamoto Y, Dutta P, Wojtkiewicz G, Courties G, Sebas M, Borodovsky A, Fitzgerald K,Nolte MW, Dickneite G, Chen JW, Anderson DG, Swirski FK, Weissleder R, Nahrendorf M.
Circulation. 2013 May 21;127(20):2038-46. [PubMed]

2012

Myocardial infarction accelerates atherosclerosis.
Dutta P, Courties G, Wei Y, Leuschner F, Gorbatov R, Robbins CS, Iwamoto Y, Thompson B, Carlson AL, Heidt T, Majmudar MD, Lasitschka F, Etzrodt M, Waterman P, Waring MT, Chicoine AT, van der Laan AM, Niessen HW, Piek JJ, Rubin BB, Butany J, Stone JR, Katus HA, Murphy SA, Morrow DA, Sabatine MS, Vinegoni C, Moskowitz MA, Pittet MJ, Libby P, Lin CP, Swirski FK, Weissleder R, Nahrendorf M.
Nature. 2012 Jul 19;487(7407):325-9. [PubMed]

2011

Enzymatic single-chain antibody tagging: a universal approach to targeted molecular imaging and cell homing in cardiovascular disease.
Ta HT, Prabhu S, Leitner E, Jia F, von Elverfeldt D, Jackson KE, Heidt T, Nair AK, Pearce H, von Zur Muhlen C, Wang X, Peter K, Hagemeyer CE.
Circ Res. 2011 Aug 5;109(4):365-73. [PubMed]

Activated platelets in carotid artery thrombosis in mice can be selectively targeted with a radiolabeled single-chain antibody.
Heidt T, Deininger F, Peter K, Goldschmidt J, Pethe A, Hagemeyer CE, Neudorfer I, Zirlik A, Weber WA, Bode C, Meyer PT, Behe M, von Zur Mühlen C.
PLoS One. 2011 Mar 30;6(3):e18446. [PubMed]

2007

Cyclin D1 expression is induced by viral BARF1 and is overexpressed in EBV-associated gastric cancer. Thorsten Wiech, Elisabeth Nikolopoulos, Silke Lassman, Timo Heidt, Anja Schöpflin, Mario Sarbia, Martin Werner, Yuko Shimizu, Emna Sakka, Tadamasa Ooka, Axel zur Hausen
Virchows Archive. 2007 Jun;452(6):621-7. [PubMed]