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Universitäts-Herzzentrum Freiburg - Bad KrozingenUniversitäts-Herzzentrum Freiburg - Bad Krozingen

First transfemoral percutaneous edge-to-edge repair of the tricuspid valve using the MitraClip system.
Wengenmayer T, Zehender M, Bothe W, Bode C, Grundmann S.
EuroIntervention. 2016 Apr 20;11(13):1541-4.

Response to Letter Regarding Article, "MicroRNA-155 Exerts Cell-Specific Antiangiogenic but Proarteriogenic Effects During Adaptive Neovascularization".
Pankratz F, Bemtgen X, Zeiser R, Leonhardt F, Kreuzaler S, Hilgendorf I, Smolka C, Helbing T, Hoefer I, Esser JS, Kustermann M, Moser M, Bode C, Grundmann S.
Circulation. 2015 Dec 8;132(23):e376.

MicroRNA-155-deficient dendritic cells cause less severe GVHD through reduced migration and defective inflammasome activation.
Chen S, Smith BA, Iype J, Prestipino A, Pfeifer D, Grundmann S, Schmitt-Graeff A, Idzko M, Beck Y, Prinz G, Finke J, Duyster J, Zeiser R.
Blood. 2015 Jul 2;126(1):103-12

MicroRNA-132/212 family enhances arteriogenesis after hindlimb ischemia through modulation of the Ras-MAPK pathway.
Lei Z, van Mil A, Brandt MM, Grundmann S, Hoefer I, Smits M, El Azzouzi H, Fukao T, Cheng C, Doevendans PA, Sluijter JP. 
J Cell Mol Med. 2015 Aug;19(8):1994-2005.

MicroRNA-155 modulates P2R signaling and Th2 priming of dendritic cells during allergic airway inflammation in mice.
Zech A, Ayata CK, Pankratz F, Meyer A, Baudiß K, Cicko S, Yegutkin GG, Grundmann S, Idzko M.
Allergy. 2015 Sep;70(9):1121-9.

MicroRNA-155 aggravates ischemia-reperfusion injury by modulation of inflammatory cell recruitment and the respiratory oxi dative burst.
Eisenhardt SU, Weiss JB, Smolka C, Maxeiner J, Pankratz F, Bemtgen X, Kustermann M, Thiele JR, Schmidt Y, Bjoern Stark G, Moser M, Bode C, Grundmann S.
Basic Res Cardiol. 2015 May;110(3):32.

MicroRNA-155 Exerts Cell-Specific Antiangiogenic but Proarteriogenic Effects During Adaptive Neovascularization.
Pankratz F, Bemtgen X, Zeiser R, Leonhardt F, Kreuzaler S, Hilgendorf I, Smolka C, Helbing T, Hoefer I, Esser JS, Kustermann M, Moser M, Bode C, Grundmann S.
Circulation. 2015 May 5;131(18):1575-89.

The transcription factor HoxB5 stimulates vascular remodelling in a cytokine-dependent manner.
Fessner A, Esser JS, Bluhm F, Grundmann S, Zhou Q, Patterson C, Bode C, Moser M.
Cardiovasc Res. 2014 Feb 1;101(2):247-55.

FoxP1 stimulates angiogenesis by repressing the inhibitory guidance protein semaphorin 5B in endothelial cells.
Grundmann S, Lindmayer C, Hans FP, Hoefer I, Helbing T, Pasterkamp G, Bode C, de Kleijn D, Moser M.
PLoS One. 2013 Sep 2;8(9):e70873

Inhibition of BMP activity protects epithelial barrier function in lung injury.
Helbing T, Herold EM, Hornstein A, Wintrich S, Heinke J, Grundmann S, Patterson C, Bode C, Moser M.
J Pathol. 2013 Sep;231(1):105-16

CD26 inhibition enhances perfusion recovery in ApoE-/-mice.
Haverslag RT, de Groot D, Grundmann S, Meder B, Goumans MJ, Pasterkamp G, Hoefer IE, de Kleijn DP.
Curr Vasc Pharmacol. 2013 Jan;11(1):21-8

Distinct CD44 splice variants differentially affect collateral artery growth.
Bot PT, Grundmann S, van Royen N, Joosten SP, Schirmer SH, de Kleijn DP, Pals ST, Pasterkamp G, Piek JJ, Hoefer IE.
Curr Vasc Pharmacol. 2013 Jan;11(1):13-20.

Inflammatory neovascularization during graft-versus-host disease is regulated by αv integrin and miR -100.
Leonhardt F, Grundmann S, Behe M, Bluhm F, Dumont RA, Braun F, Fani M, Riesner K, Prinz G, Hechinger AK, Gerlach UV, Dierbach H, Penack O, Schmitt-Gräff A, Finke J, Weber WA, Zeiser R.
Blood. 2013 Apr 25;121(17):3307-18.

MicroRNAs in ischemia-reperfusion injury.
Weiss JB, Eisenhardt SU, Stark GB, Bode C, Moser M, Grundmann S.
Am J Cardiovasc Dis. 2012;2(3):237-47. Epub 2012 Jul 25.

Perturbation of the endothelial glycocalyx in post cardiac arrest syndrome.
Grundmann S, Fink K, Rabadzhieva L, Bourgeois N, Schwab T, Moser M, Bode C, Busch HJ.
Resuscitation. 2012 Jun;83(6):715-20

MicroRNA-214 inhibits angiogenesis by targeting Quaking and reducing angiogenic growth factor release.
van Mil A, Grundmann S, Goumans MJ, Lei Z, Oerlemans MI, Jaksani S, Doevendans PA, Sluijter JP.
Cardiovasc Res. 2012 Mar 15;93(4):655-65.

BMP activity controlled by BMPER regulates the proinflammatory phenotype of endothelium.
Helbing T, Rothweiler R, Ketterer E, Goetz L, Heinke J, Grundmann S, Duerschmied D, Patterson C, Bode C, Moser M.
Blood. 2011 Nov 3;118(18):5040-9.

Forkhead box protein P1 as a downstream target of transforming growth factor-β induces collagen synthesis a nd correlates with a more stable plaque phenotype.
Bot PT, Grundmann S, Goumans MJ, de Kleijn D, Moll F, de Boer O, van der Wal AC, van Soest A, de Vries JP, van Royen N, Piek JJ, Pasterkamp G, Hoefer IE.
Atherosclerosis. 2011 Sep;218(1):33-43

MicroRNA-100 regulates neovascularization by suppression of mammalian target of rapamycin in endothelial and vascular smooth muscle cells.
Grundmann S, Hans FP, Kinniry S, Heinke J, Helbing T, Bluhm F, Sluijter JP, Hoefer I, Pasterkamp G, Bode C, Moser M.
Circulation. 2011 Mar 8;123(9):999-1009.

Inflammasome activation in reperfusion injury: friendly fire on myocardial infarction?
Grundmann S, Bode C, Moser M. 
Circulation. 2011 Feb 15;123(6):574-6.

MicroRNA regulation of angiogenesis and arteriogenesis.
Hans FP, Moser M, Bode C, Grundmann S.
Trends Cardiovasc Med. 2010 Nov;20(8):253-62.

Assessment of collateral artery function and growth in a pig model of stepwise coronary occlusion.
de Groot D, Grundmann S, Timmers L, Pasterkamp G, Hoefer IE.
Am J Physiol Heart Circ Physiol. 2011 Jan;300(1):H408-14.

An ultrasound contrast agent targeted to P-selectin detects activated platelets at supra-arterial shear flow conditions.
Guenther F, von zur Muhlen C, Ferrante EA, Grundmann S, Bode C, Klibanov AL.
Invest Radiol. 2010 Oct;45(10):586-91.

Arteriogenesis requires toll-like receptor 2 and 4 expression in bone-marrow derived cells.
de Groot D, Hoefer IE, Grundmann S, Schoneveld A, Haverslag RT, van Keulen JK, Bot PT, Timmers L, Piek JJ, Pasterkamp G, de Kleijn DP.
J Mol Cell Cardiol. 2011 Jan;50(1):25-32.

Mannose-binding lectin: an ancient molecule with new implications in myocardial infarction.
Grundmann S, Bode C, Moser M.
Eur Heart J. 2010 May;31(10):1163-4.

Prosthetic valve endocarditis due to Actinomyces neuii successfully treated with antibiotic therapy.Grundmann S, Huebner J, Stuplich J, Koch A, Wu K, Geibel-Zehender A, Bode C, Brunner M.
J Clin Microbiol. 2010 Mar;48(3):1008-11.

Neurologic prognosis after cardiac arrest.
Grundmann S, Busch HJ.
N Engl J Med. 2009 Nov 12;361(20):1999; author reply 1999-2000.

Endothelial glycocalyx dimensions are reduced in growing collateral arteries and modulate leucocyte adhesion in arteriogenesi s.
Grundmann S, Schirmer SH, Hekking LH, Post JA, Ionita MG, de Groot D, van Royen N, van den Berg B, Vink H, Moser M, Bode C, de Kleijn D, Pasterkamp G, Piek JJ, Hoefer IE.
J Cell Mol Med. 2009 Sep;13(9B):3463-74.

[Cytokine-eluting stents as new drug-delivery devices for angiogenic therapy].
Grundmann S, Hoefer I, Bode C.
Hamostaseologie. 2008 Oct;28(4):195-202. Review. German.

Arteriogenesis: basic mechanisms and therapeutic stimulation.
Grundmann S, Piek JJ, Pasterkamp G, Hoefer IE.
Eur J Clin Invest. 2007 Oct;37(10):755-66.

A new intra-arterial delivery platform for pro-arteriogenic compounds to stimulate collateral artery growth via transforming growth factor-beta1 release.
Grundmann S, van Royen N, Pasterkamp G, Gonzalez N, Tijsma EJ, Piek JJ, Hoefer IE.
J Am Coll Cardiol. 2007 Jul 24;50(4):351-8.

Granulocyte-macrophage colony-stimulating factor stimulates arteriogenesis in a pig model of peripheral artery disease using clinically applicable infusion pumps.
Grundmann S, Hoefer I, Ulusans S, Bode C, Oesterle S, Tijssen JG, Piek JJ, Buschmann I, van Royen N.
J Vasc Surg. 2006 Jun;43(6):1263-9

Aspirin, but not clopidogrel, reduces collateral conductance in a rabbit model of femoral artery occlusion.
Hoefer IE, Grundmann S, Schirmer S, van Royen N, Meder B, Bode C, Piek JJ, Buschmann IR.
J Am Coll Cardiol. 2005 Sep 20;46(6):994-1001.

Leukocyte subpopulations and arteriogenesis: specific role of monocytes, lymphocytes and granulocytes.
Hoefer IE, Grundmann S, van Royen N, Voskuil M, Schirmer SH, Ulusans S, Bode C, Buschmann IR, Piek JJ. Atherosclerosis. 2005 Aug;181(2):285-93.

Anti-tumor necrosis factor-{alpha} therapies attenuate adaptive arteriogenesis in the rabbit.
Grundmann S, Hoefer I, Ulusans S, van Royen N, Schirmer SH, Ozaki CK, Bode C, Piek JJ, Buschmann I.
Am J Physiol Heart Circ Physiol. 2005 Oct;289(4):H1497-505.

Differential effects of MCP-1 and leptin on collateral flow and arteriogenesis.
Schirmer SH, Buschmann IR, Jost MM, Hoefer IE, Grundmann S, Andert JP, Ulusans S, Bode C, Piek JJ, van Royen N.
Cardiovasc Res. 2004 Nov 1;64(2):356-64.

Arteriogenesis proceeds via ICAM-1/Mac-1- mediated mechanisms.
Hoefer IE, van Royen N, Rectenwald JE, Deindl E, Hua J, Jost M, Grundmann S, Voskuil M, Ozaki CK, Piek JJ, Buschmann IR.
Circ Res. 2004 May 14;94(9):1179-85.

Invasive and non-invasive evaluation of spontaneous arteriogenesis in a novel porcine model for peripheral arterial obstructive disease.
Buschmann IR, Voskuil M, van Royen N, Hoefer IE, Scheffler K, Grundmann S, Hennig J, Schaper W, Bode C, Piek JJ.
Atherosclerosis. 2003 Mar;167(1):33-43.

Local monocyte chemoattractant protein-1 therapy increases collateral artery formation in apolipoprotein E-deficient mice but induces systemic monocytic CD11b expression, neointimal formation, and plaque progression.
van Royen N, Hoefer I, Böttinger M, Hua J, Grundmann S, Voskuil M, Bode C, Schaper W, Buschmann I, Piek JJ.
Circ Res. 2003 Feb 7;92(2):218-25.

Labor

Prof. Dr. Grundmann

Telefon: +49 761 270-70460
Telefax: +49 761 270-70450