Zu den Inhalten springen
Universitäts-Herzzentrum Freiburg - Bad KrozingenUniversitäts-Herzzentrum Freiburg - Bad Krozingen

16:00 – 17:00    Registration

Keynote Lectures and Festive Opening
Chair: Ursula Ravens

17:00 – 17:15    Welcome addresses by: Peter Kohl

17:15 – 18:00    Leslie Leinwand    TBC

18:00 – 18:45    Michael Sheetz    Appreciating force and shape: the rise of mechanotransduction in cell biology

18:45 – 19:00    Wrap-up

19:00 – 21:00    Reception    Prometheus Hall

09:00 – …     Registration            

09:15 – 09:30        Focused issue?        

Session 1: Ion Channels From Endomembranes to Sarco- / Plasma-lemma
Chair: Kate Herum (TBC)        

09:30 – 10:00    Kristi Anseth    Nuclear mechanosensing drives chromatin remodelling in persistently activated fibroblasts         

10:00 – 10:30    Tatjana Kleele     Mitochondrial membrane tension governs fission

10:30 – 11:00    Aurore Lyon    Differentiating the effects of B-adrenergic stimulation and stretch on calcium and force dynamics using a novel electromechanical cardiomyocyte model        

11:00 - 11:30    Tea (posters on display)         

11:30 – 12:00    Bailong Xiao    The mechanosensitive Piezo1 channel mediates heart mechano-chemo transduction        

12:00 – 12:30    Bo Hjorth Bentzen    SK channels and stretch-induced vulnerability to AF        

12:30 – 13:00    Neil A Turner    Channeling the force to reprogram the matrix    

13:00 - 14:30    Lunch (posters on display)    

Session 2: Scaffolding MEC: Cytoskeleton and Nanodomains
Chair: Karine Sipido (TBC)        

14:30 – 15:00    Eva Rog Zielinska    Time-resolved 3D EM to investigate mechanics of T-tub content mixing        

15:00 – 15:30    Long-Sheng Song    Junctophilin-2 in cardiac E-C coupling and beyond        

15:30 – 16:00    Alexey Glukhov     Caveolae-mediated activation of mechanosensitive chloride channels in pulmonary veins triggers atrial arrhythmogenesis        

16:00 - 16:30    Tea (posters on display)        

16:30 – 17:00    Alexander Quinn     Microtubules and TRPA1 in stretch-induced arrhythmias        

17:00 – 17:30    Two slots for selected talks (à 10+5min)        

17:30 – 19:30    Posters with refreshments, and nibbles, and more…

Session 3: ECM and Mechano-Regulation
Chair: Boris Martinac        

09:00 – 09:30    Boris Hinz    Mechanical regulation of myofibroblast phenoconversion and collagen contraction        

09:30 – 10:00    Michele Orini    Direct in-vivo assessment of global and regional mechano-electric feedback in the intact human heart        

10:00 – 10:30    Pinar Zorlutuna    Mechanotransduction at the cardiomyocyte-fibroblast interface        

10:30 -11:00    Coffee (posters on display)         

11:00 – 11:30    Rémi Peyronnet    Piezo and matrix stiffness sensing        

11:30 – 12:00    Two slots for selected talks (à 10+5min)        

12:00 - 13:30    Lunch (posters on display)        

Session 4: Tissue MEC: From the Roots to Computational Modelling Chair: Viviane Timmermann        

13:30 – 14:00    Cecilia Ferrantini    At the roots of atrial myopathy and arrhythmias: interplay between atrial dilation and genetic factors        

14:00 – 14:30    Andreu Climent    Ranolazine-mediated attenuation of mechanoelectric feedback in atrial myocyte monolayers       

14:30 – 15:00    Sandeep Pandit    Mechanisms by which ranolazine terminates paroxysmal but not persistent atrial fibrillation      

15:00 - 15:30    Tea (posters on display)        

15:30 – 16:00    David Filgueiras-Rama    Atrial remodelling characterization during atrial fibrillation progression        

16:00 – 16:30    Natalia Trayanova    Machine learning in arrhythmia and electrophysiology    

16:30 – 17:00    Two slots for selected talks (à 10+5min)        

18:00 – ...   
Optional tours: Benefits of living near a (former) volcano in Germany: a peculiar geology for astonishing wines; Of hops and malt: artisane beer craft by the Feierling family in Freiburg

Session 5: Tissue MEC Reloaded: new Tools, Technologies, and Theories
Chair: Denis Loiselle (TBC)
        

09:00 – 09:30    Vadim Fedorov    Distinct fibrotic signatures of human sinoatrial node in non-failing and failing hearts        

09:30 – 10:00    Aurelien Forget    Mechanically defined microenvironment promotes stabilization of microvasculature: novel Piezo-1+monocyte Population        

10:00 – 10:30    Kory J. Lavine    Resident Cardiac Macrophages Mediate Adaptive Myocardial Remodeling        

10:30 -11:00    Coffee (posters on display)         

11:00 – 11:30    Timothy L Domeier    TRPV4 and stretch-induced dysfunction in the aged heart        

11:30 – 12:00    Daniel Beard    Mechano-energetics        

12:00 - 13:00    Lunch (posters on display)         

Session 6: Cool tools
Chair: Ye Chen-Izu (TBC)        

13:00 – 13:30    Boris Martinac    High-throughput measurements of the viscoelastic properties of cells        

13:30 – 14:00    Cesare Terracciano    Remodelling of adult cardiac tissue subjected to physiological and pathological mechanical load in vitro: the slice model        

14:00 – 14:30    Juliane Münch    Sensing and responding of cardiomyocytes to changes of tissue stiffness        

14:30 - 15:00    Tea (posters on display)         

Closing Session
Chair: Peter Kohl         

15:00 – 15:15    Leslie Leinwand    What we’ve learned and what should we focus on next in terms of mechanisms        

15:15 – 15:30    Michael Sheetz    What we’ve learned and what should we focus on next in terms of clinical relevance        

15:30 – 16:00    Discussion, Participant feedback        

17:30 - 00:00     Meeting Dinner and Dance at Peterhofkeller        

18:00 – 18:15    Poster Awards   
Chair: Denis Loiselle & Ursula Ravens     

Important Dates:

Registration opens: Spring 2022
Conference start: 21.09.2022
Conference end: 24.09.2022

Contact:

If you are in need of assistance please contact Julia Verheyen at:
info@cardiac-mec.org